Drug design is a multifaceted process that combines scientific knowledge, computational tools, and experimental techniques to create new medications with specific therapeutic effects. At its core, drug design involves understanding the molecular interactions between a target biomolecule and a potential drug candidate. The target biomolecule could be a protein, enzyme, or nucleic acid associated with a particular disease. In the initial stages of drug design, researchers identify a target biomolecule linked to a specific medical condition. Subsequent steps involve exploring the three-dimensional structure of the target, often determined through techniques like X-ray crystallography or nuclear magnetic resonance (NMR). With this structural information, computational methods come into play to predict and analyze potential interactions between the target and various chemical compounds.
The next crucial step is the synthesis and testing of these compounds in the laboratory. Medicinal chemists work to optimize the chemical structure of the compounds for enhanced efficacy, reduced side effects, and improved pharmacokinetics. This iterative process of designing, synthesizing, and testing continues until a promising drug candidate emerges. Advancements in technology, such as artificial intelligence and machine learning, have revolutionized drug design by accelerating the analysis of vast biological datasets and predicting potential drug-target interactions. These computational approaches significantly expedite the early stages of drug discovery.
Title : Recent advances in nanomedicine: Sensors, implants, artificial intelligence, saving the environment, human studies, and more
Thomas J Webster, Hebei University of Technology, China
Title : Harnessing the unique transport properties of InAs nanowires for single molecule level sensing
Harry E Ruda, University of Toronto, Canada
Title : Photonic metasurfaces in azobenzene materials
Ribal Georges Sabat, Royal Military College of Canada, Canada
Title : Using CuO polycrystalline nanofilms as sensor for small organic molecules
Paulo Cesar De Morais, Catholic University of Brasilia, Brazil
Title : Microplastics and nanoplastics in Antartica. Consideration their impact on ecosystems and human and fauna health
Maria Cecilia Colautti, Defense University of Republic of Argentina, Argentina
Title : Surface-enhanced stimulated Raman spectroscopy with squeezed photonic states
Frank Hagelberg, East Tennessee State University, United States