Title : Thin film-embedded lipid nanostructures optimized for multi-drug co-therapies
Abstract:
Simultaneous delivery of hydrophilic and hydrophobic drugs in a single formulation are often challenging. Synergistically active molecules carrying nanoformulations face issues such as poor solubility, low drug loading, and instability leading to therapeutic failure and increased toxicity. These problems are particularly evident in combination therapies, often tested in clinical trials, where co-delivery of multiple drugs can result in incompatibility and reduced dose response. To address these limitations, we developed a dual-drug delivery system integrating lipid nanoparticles (LNPs) within a nanoscale polymeric thin film. In this system, through interfacial distinction the hydrophobic drugs are encapsulated in the core of the LNPs, while hydrophilic drugs carried by the polymer matrix, ensures effective segregation preventing undesirable interactions. This design improves both the chemical stability and solubility of the drugs while enhancing their therapeutic efficacy. Characterization demonstrates uniform dispersion of nanoparticles within the polymeric film, controlled release profile and improved stability. Furthermore, the biodegradable nature of the LNP:thinfilm contributes to the safety and efficiency. Findings show favourable biocompatibility along with significant anticancer and antibacterial activity, validating the potential of this dual-drug delivery system evaluated in vitro. The nanoformulation has distinct advantages in drug loading, regulated release and efficacy, a promising solution to the obstacles in complex multi-drug therapies.
