Investigation of gold nanocluster conjugated with gemcitabine for potent bioimaging and anti-cancer activity

Title : Investigation of gold nanocluster conjugated with gemcitabine for potent bioimaging and anti-cancer activity

Abstract:

The development of effective drug delivery strategy by employing novel nano-careers are advantageous for targeted and controlled drug release. The present work describes about such a strategy in the form of a protein stabilized ultra-small gold nanocluster as nano-career for the delivery of anticancer drug Gemcitabine. Gold nanocluster (AuNC) stabilized by bovine serum albumin (BSA) was synthesized and characterized in detail including its stability, size distribution, toxicity and photo-physical properties. It was revealed that monodispersed gold particles (~2 nm) dispersible in aqueous phase with unique optical absorption and emission characteristics (labs = 350 nm , lemi = 500 nm), high stability and minimum toxicity was obtained. Afterwards, an anticancer drug (Gemcitabine) was conjugated with the gold cluster through simple chemical mixing resulting in the formation of drug load Au nanocluster (Gem-AuNCs-BSA). The resultant Gem-AuNCs-BSA showed enhanced the delivery of therapeutic drugs to cancer cells with better efficacy than free Gemcitabine.

Biography:

Tushar Tyagi is a forensic pharmacist and research scholar at National Forensic Sciences University, Gandhinagar, Gujarat. He completed his bachelor degree from Mahatma Jyotiba Phule Rohilkhand university. His academic performance is immaculate and exemplary while his exposure to the co- curricular activities is noteworthy. His first rank with a CGPA of 8.63 in Masters in forensic Pharmacy at National Forensic Sciences Universityis a true indicator of his knowledge but does not highlight his characteristics as a hardworking, inspired individual who is always up for a challenging task. He has been awarded research grant under Student Start-Up an Innovation Policy (SSIP)- 2020 by Government of Gujarat, India for the project titled ‘Optimization and Technology Transfer of Self-Emulsion in Drug Delivery System (SEDDS) to Pilot Scale’. He has also qualified National level exam [Graduate Pharmacy Aptitude Test (GPAT) and UGC-NET in the field of Forensic Science], he also works as Research assistant in DBT-Birac sponsored project Title: Liposome based Inhalation system for aminoglycoside drug delivery.