Title : Photothermal-responsive nanostructured materials for biomedical applications
Abstract:
Luminescent and photothermal nanostructured materials are one of the most important achievements in the fast-growing field of nanotechnology. The combination of multi-responsive Shell with luminescent and photothermal Core has led to promising applications in various fields. These nanosystems are largely studied as promising photothermal agents in emerging nanotechnologies such as photoinduced-enzymatic reaction, photothermal antibacterial effect, photothermal and photodynamic therapies (PTT and PDT), gene-therapy and photothermal triggered drug and gene delivery.
In our laboratories we have developed innovative photochemical and chemical preparation methods for the production of photothermal nanostructured materials including: i) photothermal carbon based core-shell nanocomposites ii) Carbonized polymers nanodots, iii) gold-nanostructures, iv) water-soluble β-cyclodextrin/metal (Pt) and β-cyclodextrin/metal oxide (Co3O4) nanoparticles as photothermal agents for photo-induced enzymatic reaction, v) multicolors and photothermal boron-doped carbon dots for bioimaging and vi) TiO2/AuNPs/PNIPAM nanocomposites for photothermal and photocatalytic dual-effect triggered by visible/UV light exposition.
The nanostructured materials, whose design was supported by Molecular Dynamic simulation investigations, exhibited high photothermal conversion efficiency and no toxicity to eukaryotic cells. Experiments confirmed also an excellent thermally induced activity to be used for biomedical applications.
Audience take-away:
- To increase the knowledge about the photothermal effect and the photothermal nanostructured materials.
- How to perform photothermal experiments.
- How to design photothermal materials.
